Enhancing focus, alertness, and cognitive function can profoundly improve overall quality of life. Just as our bodies need proper nutrition for optimal physical health, maintaining peak cognitive performance requires essential support. With advancing age, cells face increased oxidative stress, making cognitive nutrition critically important. Novusetin is specially formulated to bolster cognitive health by effectively managing oxidative stress and promoting a balanced inflammatory response.

Novusetin is a premium fisetin extract derived from the Japanese fruit wax tree (Rhus succedanea). Standardized to contain not less than 95% fisetin, it offers high stability and solubility. Rigorous research at the prestigious Salk Institute for Biological Studies demonstrates that fisetin safeguards neurological function, preserves cellular integrity, maintains healthy brain function, and fosters the growth of neuronal cells.

Novusetin stands out for its ability to cross the blood-brain barrier, actively enhancing signaling pathways associated with long-term memory. As a flavonol in the bioflavonoid polyphenol family, Novusetin serves as a potent antioxidant, further supporting cognitive resilience and vitality.

Health Benefits: Antioxidant Support General Wellbeing Mental Health

ORDER DETAILS:

*If you are interested in the price of the active ingredient or the corresponding finished food supplement, please do not hesitate to contact us directly for more information.

Standardized to Fisetin – provides NLT 95% Fisetin
Fisetin is a natural occurring flavonol (a bioflavonoid antioxidant) from the Japanese wax tree Rhus succedanea
High ORAC Value – 23,000 micromole TE/g
Fisetin increases the intracellular levels of glutathione & activate key neurotrophic factor signaling pathways
Reduction of lipoxygenase activity and anti-infalmmatory activity against microglial cells
Great Stability & Solubility
Pure & Non-GMO – free of preservatives, additives, and artificial colors & flavors
Daily Dose – recommended 50-125mg/day
2022 Health Canada has assigned Novusetin® (fisetin extract) a Natural Product Number (NPN; #80117026)

Supports cognitive health*
Protects against oxidative stress, reducing cellualr damage*
Stimulates neuronal cell growth and maintains cellular integrity*
Helps manage inflammation in the brain*
Stimulates signaling pathways associated with long-term memory function*
Support longevity, potentillay aiding in anti-aging processes*

*These statements have not been evaluated by the US Food & Drug Administration or the European Food and Safety Authority. This product is not intended to diagnose, treat, cure, or prevent any disease.

The flavonoid fisetin reduces multiple physiological risk factors for dementia; P Maher; Neurochemistry International; Volume 178, September 2024, 105805
The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases; GBjorklund; Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04321-2
Neuroprotective role of Fisetin in Alzheimer’s disease: An overview of potential mechanism and clinical findings; F Nabizadeh; doi 10.61186/Neurology Letters 2024, Vol 3, 14-25
An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways; X. Tang; Biomedicines. 2023 Nov; 11(11): 2878.
Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection; O. Elsallabi; Molecules 2022 27(3):738
The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress; S. Shams; Front Pharmacol. 2022; 13: 1015835
Amyloid-beta peptide and tau protein crosstalk in Alzheimer′s disease.; A. Roda; Neural Regen. Res. 2022;17:1666.
Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. A.R. Ravula at al; Eur. J. Pharmacol. 2021;910:174492.
Preventing and Treating Neurological Disorders with the Flavonol Fisetin; P. Maher; Brain Plasticity 6 (2020) 155–166
New Perspectives for Fisetin; G. Drynkiewicz at al.; Front Chem. 2019; 7: 697.
Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function; P. Maher at al.; Front Biosci (Schol Ed). 2015 Jun 1; 7: 58–82.
A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives;P. Maher; Free Rad Res. 2006;40:1105–1111
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory; P. Maher at al.; Proc Natl Acad Sci USA. 2006;103:16568–16573.